Trenbolone Acetate Wikipedia

Trenbolone Acetate Wikipedia


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Trenbolone Acetate


Contents













Trenbolone Acetate

A potent anabolic steroid derived from nandrolone. It is used primarily in veterinary medicine to promote growth in livestock but is also misused in bodybuilding for its muscle-building effects.




Uses


Veterinary uses

In cattle, it increases weight gain and feed efficiency. Administered via implant pellets or injections.




Non-medical uses

Commonly used in bodybuilding to enhance muscle mass and strength despite lacking FDA approval for human use.




Medical uses

Rarely prescribed off-label for severe muscle wasting or hormonal deficiencies, though alternatives are typically preferred due to side effects.





Side Effects


Androgenic

Acne, hair loss, aggression, and virilization in females. May cause male pattern baldness.




Hypogonadism

Prolonged use suppresses natural testosterone production, leading to testicular atrophy and infertility.




Cardiovascular

Risk of increased LDL cholesterol, hypertension, and thrombosis due to its 17α-alkylated structure.




"Tren cough"

Respiratory irritation causing persistent dry coughing in some users, attributed to metabolic byproducts.




Estrogenic and progestogenic

Lacks estrogenic activity but exhibits strong progestogenic effects, potentially causing menstrual disturbances or breast tenderness in women.





Pharmacology


Pharmacodynamics

Binds to androgen receptors, promoting protein synthesis, nitrogen retention, and red blood cell production.




Pharmacokinetics

Rapid onset (2–4 hours) after injection. Shorter active life (2–3 days) compared to other trenbolone esters due to acetate chain.





Chemistry


Structure–Activity Relationships

Modification of nandrolone’s structure with a trenbolone ring enhances binding affinity and anabolic strength. The 17β-hydroxy group ensures steroid activity.





History

Synthesized in the 1960s by Roussel-Uclaf for veterinary use. Withdrawn from human markets due to severe side effects but remains widely used in livestock.




Society and Culture


Generic names

Trenbolone acetate, Finaplix (pellet form).




Brand names

Finasteride (unrelated), Revalor-XL.




Distribution and regulation

Banned for human use in the US, EU, and Australia. Classified as a Schedule II drug under the Controlled Substances Act in some regions.




Doping in sports

Prohibited by WADA due to performance-enhancing effects. Commonly detected in bodybuilding and strength-based athletics.





References

Trenbolone Acetate. (n.d.). Wikipedia.
National Center for Biotechnology Information. PubChem Compound Summary for CID 54630183, Trenbolone acetate.




Further Reading

Steroid Profiles: Trenbolone Acetate. Underground Steroid Database.




External Links